Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages

BackgroundMelanoma has the highest mortality rate among all the types of skin cancer.In melanoma, M2-like tumor-associated macrophages (TAMs) are associated with the invasiveness of tumor cells and a poor prognosis.Hence, the depletion or reduction of M2-TAMs is a therapeutic strategy for the inhibition of tumor progression.The aim of this study wa

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Dissecting sexual minority subgroup differences in the association between depression, anxiety, and cognitive difficulties.

IntroductionA growing body of research has demonstrated extensive mental health disparities affecting sexual minority Cocktail Napkins populations, yet little research has assessed how these disparities may affect cognitive functioning among subgroups of sexual minorities.MethodsData come from the 2021 National Health Information Survey (NHIS).Surv

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Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

BackgroundGallbladder cancer (GBC) is a mortal malignancy with limited therapeutic strategies.We aimed to develop novel immune scoring systems focusing on B7-H3, B7-H4, and HHLA2.We further investigated their potential clinical effects in predicting survival and immunotherapeutic efficacy for GBC.MethodsThis was a retrospective cohort study in a si

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